Dr. Chang's clinical practice is based at the Lucile Packard Children's Hospital, and is focused on Pediatric Otology. He has specific clinical interests in congenital hearing loss, congenital ear anomalies, pediatric cochlear implantation, microtia and atresia reconstruction, and bone conduction implants. His research interests are also in hearing loss, and include neonatal hearing screening, genetics of hearing loss, otoacoustic emissions, auditory physiology, and ototoxicity. He developed the Chang and SIOP Ototoxicity Grading Scales, and is actively involved in several human clinical trials looking at the prevention of cisplatin ototoxicity that may drastically decrease the number of children developing hearing loss after chemotherapy.