Daniel M. Trifiletti, M.D., is a radiation oncologist at Mayo Clinic Comprehensive Cancer Center in Jacksonville, Florida. Dr. Trifiletti treats cancers and conditions including brain tumors, spine tumors, pituitary tumors and skull base tumors, with a special emphasis on the use of radiation therapy. He is an expert in radiotherapy and radiosurgery with an interest in clinical trials to advance the treatment of cancers using radiation therapy. Radiation oncologists work closely with medical oncologists, surgeons and other professionals at Mayo Clinic to offer you treatment options that best suit your needs and goals. Mayo Clinic is the #1 hospital in Florida, according to U.S. News & World Report. Mayo Clinic Comprehensive Cancer Center is a National Cancer Institute (NCI)-designated comprehensive cancer center.