Molecular Immunology- I have expertise in next-generation sequencing-based assays of immune repertoires and computational analysis of the immune repertoire. I direct a research lab that performs immune repertoire profiling of antibody gene rearrangements in B cells and T cell receptor gene rearrangements in T cells. Immune repertoire profiling can be used clinically for the evaluation of malignant and non-malignant clonal expansions, clone tracking, minimal residual disease assessment, evaluation of immune responses and immunologic disorders ranging from immunodeficiency to autoimmunity. I am the past-president of the Adaptive Immune Receptor Repertoire (AIRR) Community, an international group of investigators who study immune repertoires and share data.
Flow Cytometry- I have expertise in clinical and translational immunophenotyping experiments. I direct the Human Immunology Core which develops and performs multicolor immunophenotyping panels and other translational immunology assays for early-phase clinical trials. I am familiar with human B cell lymphocyte maturation, but also provide input into the design of immunophenotyping panels for malignant B and T cell disorders. I also serve as a consultant to HUP allergy immunology physicians who use clinical flow cytometry data as part of an immunodeficiency evaluation.
Autoimmune and infectious disease serology- I have expertise in autoimmune serology, autoantibody profiling and serologic assays for infectious diseases including SARS-CoV-2 and lyme disease. I am the Associate Director of the Clinical Immunology laboratory at the Hospital of the University of Pennsylvania, which performs a wide range of clinical assays.
HLA typing and allosensitization evaluations- I have expertise in HLA and anti-HLA immune responses, and provide input into clinical test design, evaluation and test reporting for the HLA lab at the Hospital of the University of Pennsylvania.
Primary Specialty
Pathologist
GenderFemale
EducationUniversity of Pennsylvania School of Medicine
TrainingHospital of the University of Pennsylvania